Open AccessPedigree Data Analysis With Crossover Interference
Author(s) -
Sharon R. Browning
Publication year - 2003
Publication title -
genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.792
H-Index - 246
eISSN - 1943-2631
pISSN - 0016-6731
DOI - 10.1093/genetics/164.4.1561
Subject(s) - pedigree chart , crossover , interference (communication) , inference , linkage (software) , inheritance (genetic algorithm) , biology , sampling (signal processing) , statistics , computer science , genetics , algorithm , computational biology , data mining , artificial intelligence , mathematics , telecommunications , channel (broadcasting) , detector , gene
We propose a new method for calculating probabilities for pedigree genetic data that incorporates crossover interference using the chi-square models. Applications include relationship inference, genetic map construction, and linkage analysis. The method is based on importance sampling of unobserved inheritance patterns conditional on the observed genotype data and takes advantage of fast algorithms for no-interference models while using reweighting to allow for interference. We show that the method is effective for arbitrarily many markers with small pedigrees.