Open AccessGenetic Diversity in Yeast Assessed With Whole-Genome Oligonucleotide Arrays
Author(s) -
Elizabeth A. Winzeler,
Cristian I. Castillo-Davis,
Guy Oshiro,
David Liang,
Daniel R. Richards,
Yingyao Zhou,
Daniel L. Hartl
Publication year - 2003
Publication title -
genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.792
H-Index - 246
eISSN - 1943-2631
pISSN - 0016-6731
DOI - 10.1093/genetics/163.1.79
Subject(s) - biology , genetics , genome , subtelomere , chromosome , gene , gene density , population , genetic diversity , genetic variation , whole genome sequencing , computational biology , genome evolution , demography , sociology
The availability of a complete genome sequence allows the detailed study of intraspecies variability. Here we use high-density oligonucleotide arrays to discover 11,115 single-feature polymorphisms (SFPs) existing in one or more of 14 different yeast strains. We use these SFPs to define regions of genetic identity between common laboratory strains of yeast. We assess the genome-wide distribution of genetic variation on the basis of this yeast population. We find that genome variability is biased toward the ends of chromosomes and is more likely to be found in genes with roles in fermentation or in transport. This subtelomeric bias may arise through recombination between nonhomologous sequences because full-gene deletions are more common in these regions than in more central regions of the chromosome.