Molecular Dissection of a Quantitative Trait Locus: A Phenylalanine-to-Tyrosine Substitution in the Transmembrane Domain of the Bovine Growth Hormone Receptor Is Associated With a Major Effect on Milk Yield and Composition | Zendy

Sarah Blott | Zendy; Jong-Joo Kim | Zendy; Sirja Moisio | Zendy; Anne SchmidtKüntzel | Zendy; Anne Cornet | Zendy; Paulette Berzi | Zendy; Nadine Cambisano | Zendy; Christine A. Ford | Zendy; Bernard Grisart | Zendy; Dave Johnson | Zendy; Latifa Karim | Zendy; Patricia Simon | Zendy; Russell G. Snell | Zendy; Richard Spelman | Zendy; Jerry Wong | Zendy; Johanna Vilkki | Zendy; Michel Georges | Zendy; Frédéric Farnir | Zendy; Wouter Coppieters | Zendy

Open Access

Molecular Dissection of a Quantitative Trait Locus: A Phenylalanine-to-Tyrosine Substitution in the Transmembrane Domain of the Bovine Growth Hormone Receptor Is Associated With a Major Effect on Milk Yield and Composition

Author(s) -

Sarah Blott,

Jong-Joo Kim,

Sirja Moisio,

Anne SchmidtKüntzel,

Anne Cornet,

Paulette Berzi,

Nadine Cambisano,

Christine A. Ford,

Bernard Grisart,

Dave Johnson,

Latifa Karim,

Patricia Simon,

Russell G. Snell,

Richard Spelman,

Jerry Wong,

Johanna Vilkki,

Michel Georges,

Frédéric Farnir,

Wouter Coppieters

Publication year - 2003

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/163.1.253

Subject(s) - biology , quantitative trait locus , genetics , linkage disequilibrium , transmembrane domain , locus (genetics) , chromosome , population , gene , genotype , haplotype , demography , sociology

We herein report on our efforts to improve the mapping resolution of a QTL with major effect on milk yield and composition that was previously mapped to bovine chromosome 20. By using a denser chromosome 20 marker map and by exploiting linkage disequilibrium using two distinct approaches, we provide strong evidence that a chromosome segment including the gene coding for the growth hormone receptor accounts for at least part of the chromosome 20 QTL effect. By sequencing individuals with known QTL genotype, we identify an F to Y substitution in the transmembrane domain of the growth hormone receptor gene that is associated with a strong effect on milk yield and composition in the general population.

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