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By deletion of 1.8 kb of sequence between cogL and his-3 and replacement with sequences of different lengths, we have generated a set of Neurospora strains in which the distance between cogL and the site at which recombination is selected varies from 1.7 to nearly 6 kb. Each of the manipulated strains includes cogL, a highly active recombination hotspot, and rec-2, thus allowing high-frequency recombination. In addition, each is a his-3 mutant, either K26 or K480. The frequency of His+ recombinants in progeny of these crosses is inversely proportional to the distance between his-3 and cog. Specifically, there is a linear relationship between log10 (recombination frequency) and the distance in base pairs, indicating that as distance decreases, the rate of interallelic recombination increases exponentially. An exponential relationship between distance separating markers and the chance of co-conversion has been found in both Drosophila and fission yeast, indicating that the extension of recombination events may be a stochastic process in most organisms. On the basis of these and additional data presented in this article, we conclude that recombination is initiated at cogL in &amp;gt;17% of meioses, that most conversion tracts are very short, and that few extend &amp;gt;14 kb.

Recombination at his-3 in Neurospora Declines Exponentially With Distance from the Initiator, cog