Open AccessCaenorhabditis elegans unc-37/groucho Interacts Genetically With Components of the Transcriptional Mediator Complex
Author(s) -
Hong Zhang,
Scott W. Emmons
Publication year - 2002
Publication title -
genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.792
H-Index - 246
eISSN - 1943-2631
pISSN - 0016-6731
DOI - 10.1093/genetics/160.2.799
Subject(s) - corepressor , caenorhabditis elegans , biology , mediator , genetics , chromatin , transcription factor , microbiology and biotechnology , gene , repressor
Groucho functions as a general corepressor by modulating chromatin structure and has a widespread role in many developmental processes. Here we show that Groucho may also interact with the basal transcriptional machinery. Mutations in Caenorhabditis elegans groucho interact with mutations in components of the transcriptional Mediator complex, resulting in synthetic lethality and loss of male sensory neurons.