Open AccessA Microsatellite-Based Multilocus Screen for the Identification of Local Selective Sweeps
Author(s) -
Christian Schlötterer
Publication year - 2002
Publication title -
genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.792
H-Index - 246
eISSN - 1943-2631
pISSN - 0016-6731
DOI - 10.1093/genetics/160.2.753
Subject(s) - biology , microsatellite , genetics , genome , statistic , selective sweep , natural selection , mutation rate , evolutionary biology , identification (biology) , selection (genetic algorithm) , gene , genotype , allele , statistics , haplotype , botany , mathematics , artificial intelligence , computer science
With the availability of completely sequenced genomes, multilocus scans of natural variability have become a feasible approach for the identification of genomic regions subjected to natural and artificial selection. Here, I introduce a new multilocus test statistic, ln RV, which is based on the ratio of observed variances in repeat number at a set of microsatellite loci in two groups of populations. The distribution of ln RV values captures demographic history of the populations as well as variation in microsatellite mutation among loci. Given that microsatellite loci associated with a recent selective sweep differ from the remainder of the genome, they are expected to fall outside of the distribution of neutral ln RV values. The ln RV test statistic is applied to a data set of 94 loci typed in eight non-African and two African human populations.