Chromosome 14 Contains Determinants That Regulate Susceptibility to Theiler's Virus–Induced Demyelination in the Mouse | Zendy

JeanFrançois Bureau | Zendy; Kristen M. Drescher | Zendy; Larry R. Pease | Zendy; Turid Vikøren | Zendy; Melaine Delcroix | Zendy; Laurie Zoecklein | Zendy; Michel Brahic | Zendy; Moses Rodriguez | Zendy

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Chromosome 14 Contains Determinants That Regulate Susceptibility to Theiler's Virus–Induced Demyelination in the Mouse

Author(s) -

JeanFrançois Bureau,

Kristen M. Drescher,

Larry R. Pease,

Turid Vikøren,

Melaine Delcroix,

Laurie Zoecklein,

Michel Brahic,

Moses Rodriguez

Publication year - 1998

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/148.4.1941

Subject(s) - biology , multiple sclerosis , demyelinating disease , major histocompatibility complex , virus , genetics , genetic linkage , chromosome , gene , virology , immunology

Theiler's murine encephalomyelitis virus causes a chronic demyelinating disease in susceptible strains of mice that is similar to human multiple sclerosis. Several nonmajor histocompatibility complex–linked genes have been implicated as determinants of susceptibility or resistance to either demyelination or virus persistence. In this study, we used linkage analysis of major histocompatibility complex identical H-2d (DBA/2J × B10.D2) F2 intercross mice to identify loci associated with susceptibility to virus-induced demyelinating disease. In a 20-cM region on chromosome 14, we identified four markers, D14Mit54, D14Mit60, D14Mit61, and D14Mit90 that are significantly associated with demyelination. Because two peaks were identified, one near D14Mit54 and one near D14Mit90, it is possible that two loci in this region are involved in controlling demyelination.

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