A Genetic Screen to Identify Components of the sina Signaling Pathway in Drosophila Eye Development | Zendy

Thomas P. Neufeld | Zendy; Amy Tang | Zendy; Gerald M. Rubin | Zendy

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A Genetic Screen to Identify Components of the sina Signaling Pathway in Drosophila Eye Development

Author(s) -

Thomas P. Neufeld,

Amy Tang,

Gerald M. Rubin

Publication year - 1998

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/148.1.277

Subject(s) - biology , eye development , genetics , enhancer , gene , genetic screen , drosophila (subgenus) , ectopic expression , phenotype , imaginal disc , mutation , compound eye , microbiology and biotechnology , gene expression , physics , optics

Specification of the R7 photoreceptor cell in the developing Drosophila eye requires the seven in absentia (sina) gene. We demonstrate that ectopic expression of sina in all cells behind the morphogenetic furrow disrupts normal eye development during pupation, resulting in a severely disorganized adult eye. Earlier events of cell fate specification appear unaffected. A genetic screen for dominant enhancers and suppressors of this phenotype identified mutations in a number of genes required for normal eye development, including UbcD1, which encodes a ubiquitin conjugating enzyme; SR3-4a, a gene previously implicated in signaling downstream of Ras1; and a Drosophila homolog of the Sin3A transcriptional repressor.

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