Open AccessA genetic map of the mouse suitable for typing intraspecific crosses.
Author(s) -
William F. Dietrich,
Hillary Katz,
Stephen E. Lincoln,
HeeSup Shin,
Jeffrey M. Friedman,
Nicholas C. Dracopoli,
Eric S. Lander
Publication year - 1992
Publication title -
genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.792
H-Index - 246
eISSN - 1943-2631
pISSN - 0016-6731
DOI - 10.1093/genetics/131.2.423
Subject(s) - biology , genetics , inbred strain , typing , genetic linkage , gene mapping , genome , genetic marker , inheritance (genetic algorithm) , polymerase chain reaction , linkage (software) , genetic linkage map , gene , chromosome
We report the construction of a genetic linkage map of the mouse, consisting entirely of genetic markers that can be rapidly typed by polymerase chain reaction and that show a high degree of polymorphism among inbred laboratory strains. Specifically, the map contains 317 simple sequence length polymorphisms at an average spacing of 4.3 cM and is detectably linked to approximately 99% of the mouse genome. In typical crosses between inbred laboratory strains, about 50% of the markers are polymorphic, making it straightforward to follow inheritance in almost any cross.