Sequence amplification and gene rearrangement in parasitic nematode mitochondrial DNA. | Zendy

Bradley C. Hyman | Zendy; Joyce L. Beck | Zendy; Kimberly Weiss | Zendy

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Sequence amplification and gene rearrangement in parasitic nematode mitochondrial DNA.

Author(s) -

Bradley C. Hyman,

Joyce L. Beck,

Kimberly Weiss

Publication year - 1988

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/120.3.707

Subject(s) - biology , mitochondrial dna , genetics , gene , genome , tandem repeat , gene rearrangement , genomic organization , inverted repeat , extrachromosomal dna , tandem exon duplication , direct repeat , dna , microbiology and biotechnology

The nematode Romanomermis culicivorax, an obligate mosquito parasite, possesses a 26 kilobase (kb) mitochondrial genome. The unusually large size is due to transcriptionally active DNA sequences present as 3.0 kb direct tandem repeats and as inverted portions of the repeating unit located elsewhere in the mitochondrial DNA (mtDNA). The genome rearrangements involved in establishing this unusual sequence organization may have dramatically altered conventional mitochondrial gene order. Genes for subunits of the cytochrome c oxidase complex (COI and COII) are normally closely linked in animal mtDNAs, but are separated by approximately 8 kb in this mitochondrial genome.

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