Chromosomal location of the regulator of mouse alpha-fetoprotein, Afr-1. | Zendy

Elizabeth P. Blankenhorn | Zendy; Robert Duncan | Zendy; Konrad Hüppi | Zendy; Michael Potter | Zendy

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Chromosomal location of the regulator of mouse alpha-fetoprotein, Afr-1.

Author(s) -

Elizabeth P. Blankenhorn,

Robert Duncan,

Konrad Hüppi,

Michael Potter

Publication year - 1988

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/119.3.687

Subject(s) - biology , chromosome , gene , alpha (finance) , microbiology and biotechnology , oncogene , gene product , genetics , gene expression , medicine , cell cycle , construct validity , nursing , patient satisfaction

Afr-1 is a gene whose product contributes to the adult regulation of mouse alpha-fetoprotein (AFP). In Afr-1b/b homozygotes, the adult serum levels of AFP are 10- to 20-fold higher than in Afr-1a/a or Afr-1a/b mice. The studies reported here were performed to map the Afr-1 gene. Our results show that Afr-1 resides on mouse chromosome 15, approximately 25 cM from Gdc-1. Afr-1 appears to be located in close proximity to the mouse c-myc oncogene. These results are discussed with respect to the susceptibility or resistance of different BALB/c sublines (which are either Afr-1a or Afr-1b, respectively) to pristane-induced plasmacytomas.

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