Open AccessChromosomal location of the regulator of mouse alpha-fetoprotein, Afr-1.
Author(s) -
Elizabeth P. Blankenhorn,
Robert C. Duncan,
Konrad Hüppi,
Michael Potter
Publication year - 1988
Publication title -
genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.792
H-Index - 246
eISSN - 1943-2631
pISSN - 0016-6731
DOI - 10.1093/genetics/119.3.687
Subject(s) - biology , chromosome , gene , alpha (finance) , microbiology and biotechnology , oncogene , gene product , genetics , gene expression , medicine , cell cycle , construct validity , nursing , patient satisfaction
Afr-1 is a gene whose product contributes to the adult regulation of mouse alpha-fetoprotein (AFP). In Afr-1b/b homozygotes, the adult serum levels of AFP are 10- to 20-fold higher than in Afr-1a/a or Afr-1a/b mice. The studies reported here were performed to map the Afr-1 gene. Our results show that Afr-1 resides on mouse chromosome 15, approximately 25 cM from Gdc-1. Afr-1 appears to be located in close proximity to the mouse c-myc oncogene. These results are discussed with respect to the susceptibility or resistance of different BALB/c sublines (which are either Afr-1a or Afr-1b, respectively) to pristane-induced plasmacytomas.