Open AccessADDITIVE VARIATION MAINTAINED UNDER STABILIZING SELECTION: A TWO-LOCUS MODEL OF PLEIOTROPY FOR TWO QUANTITATIVE CHARACTERS
Author(s) -
A. Gimelfarb
Publication year - 1986
Publication title -
genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.792
H-Index - 246
eISSN - 1943-2631
pISSN - 0016-6731
DOI - 10.1093/genetics/112.3.717
Subject(s) - biology , locus (genetics) , genetics , pleiotropy , selection (genetic algorithm) , genetic variation , stabilizing selection , evolutionary biology , phenotype , gene , artificial intelligence , computer science
A model with two diallelic loci controlling two additive quantitative characters is suggested. One of the loci has a similar effect on both characters, whereas the second locus has an antagonistic effect on two characters. Both characters experience direct stabilizing selection. The model yields a stable polymorphic state, with both characters maintaining genetic variation. The genetic correlation between the characters at the equilibrium is zero, in spite of the pleiotropic effects of the loci controlling them.