Open AccessTHE AFFECTED SIB METHOD. I. STATISTICAL FEATURES OF THE AFFECTED SIB-PAIR METHOD
Author(s) -
Uzi Motro,
Glenys Thomson
Publication year - 1985
Publication title -
genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.792
H-Index - 246
eISSN - 1943-2631
pISSN - 0016-6731
DOI - 10.1093/genetics/110.3.525
Subject(s) - biology , genetics , allele , haplotype , human leukocyte antigen , allele frequency , population , trait , gene , demography , computer science , antigen , sociology , programming language
The distribution of the number of HLA haplotypes shared by sibs affected with the same HLA-linked disease can be used to obtain information on the genetics of the disease. Since the inception of the use of sib-pair methods for the analysis of the HLA-associated diseases, the question has been raised of how to include families with more than two affected sibs in the sib-pair analysis. This paper presents appropriate weighting schemes. A procedure for estimating the frequency of the disease allele in the general population, under the assumptions of single-allele recessive, additive, dominant and intermediate models, with negligible recombination (theta = 0) between the disease-predisposing gene and the HLA region, and no selective disadvantage of the trait, is also given. Cluster-sampling techniques are used in the analysis.