Open AccessCONSERVED LINKAGE WITHIN A 4-cM REGION OF MOUSE CHROMOSOME 9 AND HUMAN CHROMOSOME 11
Author(s) -
Tammy K. Antonucci,
Otto H. von Deimling,
Barnett B. Rosenblum,
Loren C. Skow,
Miriam H. Meisler
Publication year - 1984
Publication title -
genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.792
H-Index - 246
eISSN - 1943-2631
pISSN - 0016-6731
DOI - 10.1093/genetics/107.3.463
Subject(s) - biology , genetics , chromosome , centromere , chromosome 17 (human) , chromosome 22 , chromosome 4 , chromosome 16 , homology (biology) , chromosome 3 , gene , chromosome 21 , allele , chromosome 9 , genetic linkage
A six-point cross was carried out to determine the gene order and distances among loci on mouse chromosome 9. Our results are consistent with the following arrangement: centromere - Lap-1 - (1.2 +/- 0.8) - Es-17 - (3.0 +/- 1.0) - Ups - (1.3 +/- 0.7) - Alp-1 - (23.1 +/- 3.4) - Mod-1 - (10.9 +/- 2.6) - Acy-1. This study provides the first estimate of the distances between Es-17, Ups and Alp-1. Exceptions to the preferred association of alleles of Es-17 and Ups have been found in three feral populations and one inbred strain. Evidence is presented for the homology of this chromosome region with the ESA4 - UPS - APO-AI region on the long arm of human chromosome 11.