Open AccessGENETIC HETEROGENEITY OF RABBIT ALPHA-1-ANTITRYPSIN
Author(s) -
Friedrich Kueppers,
C C Lee,
R. R. Fox,
Juliane K. Mills
Publication year - 1984
Publication title -
genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.792
H-Index - 246
eISSN - 1943-2631
pISSN - 0016-6731
DOI - 10.1093/genetics/106.4.695
Subject(s) - biology , inbred strain , sexual dimorphism , phenotype , electrophoresis , loss of heterozygosity , microbiology and biotechnology , trypsin , genetics , genetic variation , endocrinology , enzyme , biochemistry , allele , gene
Sixteen inbred or partially inbred strains of rabbits were investigated for electrophoretic and quantitative variations of alpha-1-antitrypsin (A-1-AT). We found interindividual differences in the electrophoretic A-1-AT patterns as well as quantitative differences in the concentrations of A-1-AT and the serum trypsin-inhibiting activity. Three electrophoretic phenotypes were distinguished: M, P and MP. M was characterized by a predominant anodal A-1-AT band, and P had a major cathodal component. The MP pattern can be explained by the occurrence of the M and P components in the same serum due to heterozygosity. The P pattern was associated with an A-1-AT concentration of approximately 56% of that in sera with the M phenotype. The levels of A-1-AT in sera with the MP phenotype were intermediate between those in M and P types. In addition to the type-specific quantitative variation, we found a quantitative sexual dimorphism of a moderate degree: Female rabbits had A-1-AT concentrations 16% less than males.