Open AccessGENETIC ANALYSIS OF B2t, THE STRUCTURAL GENE FOR A TESTIS-SPECIFIC β-TUBULIN SUBUNIT IN DROSOPHILA MELANOGASTER
Author(s) -
Kenneth J. Kemphues,
Elizabeth C. Raff,
Thomas C. Kaufman
Publication year - 1983
Publication title -
genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.792
H-Index - 246
eISSN - 1943-2631
pISSN - 0016-6731
DOI - 10.1093/genetics/105.2.345
Subject(s) - biology , locus (genetics) , genetics , mutant , gene , drosophila melanogaster , genetic analysis
Genetic analysis of the B2t locus has resulted in the recovery of four recessive mutations in the B2t structural gene and a deficiency that deletes the locus. Two of the mutations were recovered as suppressors of B2tD, a dominant male sterile mutation at the locus, and two were induced on wild-type chromosomes. All four mutant genes encode beta 2-tubulin subunits that are synthesized at normal rates but do not accumulate. All mutants are completely male sterile as homozygotes.