Open AccessSELECTION FOR THE α-THALASSEMIA GENES
Author(s) -
Shozo Yokoyama
Publication year - 1983
Publication title -
genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.792
H-Index - 246
eISSN - 1943-2631
pISSN - 0016-6731
DOI - 10.1093/genetics/103.1.143
Subject(s) - heterozygote advantage , biology , genetics , gene , thalassemia , globin , selection (genetic algorithm) , polymorphism (computer science) , compound heterozygosity , genotype , phenotype , artificial intelligence , computer science
Extremely high incidences of single and double deletions of alpha-globin genes are known among Asian populations. To study possible mechanisms for the maintenance of such deletions, mathematical analyses have been conducted. It has been shown that a stable polymorphism can be achieved easily through heterozygote advantage using deterministic models. The results strongly suggest that high incidences of single and double deletion of alpha-globin genes among Asian populations are maintained by some type of heterozygote advantage.