A Case of mild idiopathic adulthood ductopenia and brief review of literature | Zendy

Aung Kaung | Zendy; Vinay Sundaram | Zendy; Deepti Dhall | Zendy; Tram T. Tran | Zendy

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A Case of mild idiopathic adulthood ductopenia and brief review of literature

Author(s) -

Aung Kaung,

Vinay Sundaram,

Deepti Dhall,

Tram T. Tran

Publication year - 2014

Publication title -

gastroenterology report

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.934

H-Index - 26

eISSN - 2052-0034

pISSN - 2304-1412

DOI - 10.1093/gastro/gou048

Subject(s) - medicine , cholestasis , liver transplantation , elevated alkaline phosphatase , liver biopsy , gastroenterology , alkaline phosphatase , bile duct , intrahepatic bile ducts , pathology , biopsy , transplantation , enzyme , biochemistry , chemistry

Mild idiopathic adulthood ductopenia (IAD) is a rare cholestatic disease of unknown cause and characterized by interlobular bile duct loss in less than 50% of the portal tracts. We describe the case of a middLe-aged male who presented with persistent elevation of transaminases and alkaline phosphatase. He had a normal biliary tree on endoscopic retrograde cholangiopathy and negative anti-mitochondrial antibody. His liver biopsy specimen showed chronic biliary disease, duct loss in 4 out of 15 portal tracts and prominent cholestasis. Based on the work-up, he likely had mild IAD. Liver transplantation would be necessary if his disease becomes progressive.

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