Open AccessCandida glabrata: new tools and technologies—expanding the toolkit
Author(s) -
Hsueh-lui Ho,
Ken Haynes
Publication year - 2015
Publication title -
fems yeast research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.991
H-Index - 92
eISSN - 1567-1364
pISSN - 1567-1356
DOI - 10.1093/femsyr/fov066
Subject(s) - candida glabrata , biology , candida albicans , virulence , microbiology and biotechnology , fungal pathogen , pathogen , azole , corpus albicans , antifungal , genetics , gene
In recent years, there has been a noticeable rise in fungal infections related to non-albicans Candida species, including Candida glabrata which has both intrinsic resistance to and commonly acquired resistance to azole antifungals. Phylogenetically, C. glabrata is more closely related to the mostly non-pathogenic model organism Saccharomyces cerevisiae than to other Candida species. Despite C. glabrata's designation as a pathogen by Wickham in 1957, relatively little is known about its mechanism of virulence. Over the past few years, technology to analyse the molecular basis of infection has developed rapidly, and here we briefly review the major advances in tools and technologies available to explore and investigate the virulence of C. glabrata that have occurred over the past decade.