Open AccessShort-chain fatty acid and fecal microbiota profiles are linked to fibrosis in primary biliary cholangitis
Author(s) -
Craig Lammert,
Andrea Shin,
Huiping Xu,
Christopher M. Hemmerich,
Thomas M. O’Connell,
Naga Chalasani
Publication year - 2021
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1093/femsle/fnab038
Subject(s) - feces , metabolome , gut flora , fibrosis , biology , microbiome , medicine , bile acid , microbiology and biotechnology , gastroenterology , immunology , metabolomics , biochemistry , bioinformatics
The gut microbiota and metabolome could play a role in primary biliary cholangitis (PBC) progression. We aimed to assess fecal microbiota and fecal short-chain fatty acids (SCFAs) in PBC according to fibrosis. In a cross-sectional study of 23 PBC patients, fecal microbiota and SCFAs were determined using 16S rRNA sequencing and nuclear magnetic resonance spectroscopy, respectively. Fecal acetate and SCFAs were higher in advanced fibrosis. Advanced fibrosis microbiota exhibited decreased alpha diversity, increased Weisella and a distinct community composition. SCFAs correlated with individual taxa in non-advanced fibrosis. Fecal microbiota and SCFAs correspond to fibrosis in PBC.