Open AccessNon-invasive detection of exercise-induced cardiac conduction abnormalities in sudden cardiac death survivors in the inherited cardiac conditions
Author(s) -
Kevin Leong,
Fu Siong Ng,
Matthew Shun-Shin,
Michael KoaWing,
Norman Qureshi,
Zachary I. Whinnett,
N Linton,
David Lefroy,
Dárrel P. Francis,
Siân E. Harding,
D. Wyn Davies,
Nicholas S Peter,
Phang Boon Lim,
Elijah R. Behr,
Pier D. Lambiase,
Amanda Varnava,
Prapa Kanagaratnam
Publication year - 2020
Publication title -
europace
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.119
H-Index - 102
eISSN - 1532-2092
pISSN - 1099-5129
DOI - 10.1093/europace/euaa248
Subject(s) - medicine , cardiology , interquartile range , brugada syndrome , ventricular fibrillation , ventricle , sudden cardiac death , hypertrophic cardiomyopathy , exertion
Rate adaptation of the action potential ensures spatial heterogeneities in conduction across the myocardium are minimized at different heart rates providing a protective mechanism against ventricular fibrillation (VF) and sudden cardiac death (SCD), which can be quantified by the ventricular conduction stability (V-CoS) test previously described. We tested the hypothesis that patients with a history of aborted SCD due to an underlying channelopathy or cardiomyopathy have a reduced capacity to maintain uniform activation following exercise.