Circulating microRNA as predictors for exercise response in heart failure with reduced ejection fraction | Zendy

Isabel Witvrouwen | Zendy; Andreas B. Gevaert | Zendy; Nadine Possemiers | Zendy; Paul Beckers | Zendy; Anne Vorlat | Zendy; Hein Heidbüchel | Zendy; Steven Van Laere | Zendy; Amaryllis H. Van Craenenbroeck | Zendy; Emeline M. Van Craenenbroeck | Zendy

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Circulating microRNA as predictors for exercise response in heart failure with reduced ejection fraction

Author(s) -

Isabel Witvrouwen,

Andreas B. Gevaert,

Nadine Possemiers,

Paul Beckers,

Anne Vorlat,

Hein Heidbüchel,

Steven Van Laere,

Amaryllis H. Van Craenenbroeck,

Emeline M. Van Craenenbroeck

Publication year - 2021

Publication title -

european journal of preventive cardiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.669

H-Index - 101

eISSN - 2047-4881

pISSN - 2047-4873

DOI - 10.1093/eurjpc/zwaa142

Subject(s) - medicine , ejection fraction , heart failure , cardiology , heart failure with preserved ejection fraction , microrna , fraction (chemistry) , gene , biochemistry , chemistry , organic chemistry

Exercise training is a powerful adjunctive therapy in patients with heart failure with reduced ejection fraction (HFrEF), but ca. 55% of patients fail to improve VO2peak. We hypothesize that circulating microRNAs (miRNAs), as epigenetic determinants of VO2peak, can distinguish exercise responders (ER) from exercise non-responders (ENR).

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