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Prediction and mechanism of frequent ventricular premature contractions related to haemodynamic deterioration
Author(s) -
Kuroki Kenji,
Tada Hiroshi,
Seo Yoshihiro,
Ishizu Tomoko,
Igawa Masayuki,
Yamasaki Hiro,
Igarashi Miyako,
Machino Takeshi,
Naruse Yoshihisa,
Sekiguchi Yukio,
Murakoshi Nobuyuki,
Aonuma Kazutaka
Publication year - 2012
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1093/eurjhf/hfs095
Subject(s) - medicine , pulmonary wedge pressure , cardiology , preload , hemodynamics , heart failure , central venous pressure , ventricular pressure , mitral regurgitation , blood pressure , heart rate
Aim Frequent ventricular premature contractions (VPCs) may cause haemodynamic deterioration and reversible left ventricular (LV) dysfunction. We aimed to clarify this mechanism. Methods and results The haemodynamics, echocardiographic parameters, and plasma brain natriuretic peptide (BNP) level were assessed in 31 patients with idiopathic, frequent VPCs undergoing radiofrequency catheter ablation. The patients were classified into two groups according to the presence ( n = 19) or absence ( n = 12) of marked augmentation of the pulmonary capillary wedge pressure (PCWP) following VPCs (VPC‐induced‐PCWP augmentation; VI‐PA). The VI‐PA(+) group was defined as those with a peak PCWP of >15 mmHg measured after a VPC. Before the ablation, the mean PCWP, right atrial pressure (RAP), left ventricular end‐diastolic pressure (LVEDP), and plasma BNP level were significantly greater in the VI‐PA(+) group than in the VI‐PA(–) group. In the VI‐PA(+) group, the mean PCWP, RAP, LVEDP, and cardiac index all improved immediately after a successful ablation. At 7.4 ±0.9 months after the ablation, almost all the echocardiographic parameters and plasma BNP level also significantly improved in the VI‐PA(+) group, and the magnitude of the improvement in those parameters measured was greater in the VI‐PA(+) group than in the VI‐PA(–) group. The left atrial contractions during mitral valve closure during VPCs caused a marked pulmonary venous flow regurgitation and VI‐PA. VPC coupling intervals of <500 ms and the presence of a following P‐wave of <300 ms predicted VI‐PAs with a high accuracy. Conclusions The VI‐PA may be the main mechanism of the haemodynamic deterioration in patients with frequent VPCs. This haemodynamically deteriorating subgroup could be identified by the surface electrocardiogram and improved dramatically with catheter ablation.