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Echocardiographic quantification of regional deformation helps to distinguish isolated left ventricular non‐compaction from dilated cardiomyopathy
Author(s) -
Niemann Markus,
Liu Dan,
Hu Kai,
Cikes Maja,
Beer Meinrad,
Herrmann Sebastian,
Gaudron Philipp Daniel,
Hillenbrand Hanns,
Voelker Wolfram,
Ertl Georg,
Weidemann Frank
Publication year - 2012
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1093/eurjhf/hfr164
Subject(s) - dilated cardiomyopathy , medicine , cardiology , ventricle , basal (medicine) , magnetic resonance imaging , left ventricular noncompaction , cardiomyopathy , deformation (meteorology) , differential diagnosis , heart failure , doppler imaging , radiology , diastole , pathology , materials science , composite material , insulin , blood pressure
Aims Pronounced trabeculation is presented in both left ventricular non‐compaction (LVNC) and dilated cardiomyopathy (DCM), which sometimes makes the differentiation difficult. We hypothesized that echocardiographic deformation analysis would help to differentiate these two cardiomyopathies. Methods and results We investigated 15 patients with LVNC (9 males; 42 ± 9 years), 15 age‐ and gender‐matched DCM patients, and 15 healthy controls. The echocardiographic diagnosis of LVNC was confirmed by magnetic resonance imaging. In all subjects standard echocardiography and tissue Doppler imaging (TDI) to study regional LV deformation were carried out. No statistical difference was observed in standard echocardiographic parameters between LVNC and DCM patients. Compared with controls, both patient groups showed significantly reduced annular displacements (septal: controls 14 ± 2 mm vs. DCM 6 ± 3 mm vs. LVNC 7 ± 3 mm) and reduced strain values of the LV segments. A characteristic deformation pattern with significantly higher values in the LV base compared with the apex was observed in patients with LVNC by deformation measurements with TDI. This gradient was found particularly in the lateral and inferior wall but spared the anteroseptal wall; non‐compaction was not found in basal segments throughout the ventricle and also spared the anteroseptal midventricular wall. In DCM the strain and strain rate values were homogeneously reduced in all LV segments. Conclusion A special regional deformation pattern (preserved deformation in basal segments of LVNC) seems to be of major diagnostic help for the definite differential diagnosis of LVNC and DCM.