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Aldosterone and cortisol predict medium‐term left ventricular remodelling following myocardial infarction
Author(s) -
Weir Robin A.P.,
Tsorlalis Ioannis K.,
Steedman Tracey,
Dargie Henry J.,
Fraser Robert,
McMurray John J.V.,
Connell John M.C.
Publication year - 2011
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1093/eurjhf/hfr129
Subject(s) - medicine , aldosterone , cardiology , myocardial infarction , heart failure , term (time) , ventricular remodeling , infarction , physics , quantum mechanics
Mineralocorticoid receptor (MR) antagonists improve cardiovascular outcomes in patients with heart failure complicating acute myocardial infarction (AMI) and in chronic heart failure. It is unclear whether these beneficial effects are due solely to aldosterone blockade, as MR has a similar affinity for cortisol. We examined the relationships between plasma and urinary steroid hormones and left ventricular (LV) remodelling in patients with LV dysfunction following AMI.