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The prognostic importance of lung function in patients admitted with heart failure
Author(s) -
Iversen Kasper Karmark,
Kjaergaard Jesper,
Akkan Dilek,
Kober Lars,
TorpPedersen Christian,
Hassager Christian,
Vestbo Jorgen,
Kjoller Erik
Publication year - 2010
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1093/eurjhf/hfq050
Subject(s) - medicine , spirometry , heart failure , vital capacity , cardiology , ejection fraction , hazard ratio , confidence interval , univariate analysis , pulmonary function testing , proportional hazards model , multivariate analysis , lung function , lung , asthma , diffusing capacity
Aims The purpose of the present study was to determine the prognostic importance for all‐cause mortality of lung function variables obtained by spirometry in an unselected group of patients admitted with heart failure (HF). Methods and results This was a prospective prognostic study performed as part of the EchoCardiography and Heart Outcome Study (ECHOS). This analysis included 532 patients admitted with a clinical diagnosis of HF. All patients underwent spirometry and echocardiography and the diagnosis of HF was made according to established criteria. Mean forced expiratory volume in 1 s (FEV 1 ) was 65% of the predicted value [95% confidence interval (CI) 63–67%], mean forced vital capacity (FVC) was 71% of predicted (95% CI 69–72%), and FEV 1 /FVC was 0.72 (95% CI 0.71–0.73). FEV 1 , FVC, and FEV 1 /FVC were all significant prognostic factors for all‐cause mortality in univariate analyses. In a multivariate analysis, FEV 1 had independent prognostic value (hazard ratio 0.86 per 10% change, P < 0.001) after adjusting for demographic variables, known risk factors, ejection fraction, and self‐reported chronic obstructive pulmonary disease. Conclusion Pulmonary function provides significant prognostic information for all‐cause mortality in patients admitted with HF. Spirometry therefore seems to be worth considering for all patients admitted with HF in order to identify patients at high risk.