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Plasma apelin concentration is depressed following acute myocardial infarction in man
Author(s) -
Weir Robin A.P.,
Chong Kwok Shiong,
Dalzell Jonathan R.,
Petrie Colin J.,
Murphy Charles A.,
Steedman Tracey,
Mark Patrick B.,
McDonagh Theresa A.,
Dargie Henry J.,
McMurray John J.V.
Publication year - 2009
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1093/eurjhf/hfp043
Subject(s) - apelin , medicine , ejection fraction , myocardial infarction , cardiology , heart failure , inotrope , natriuretic peptide , norepinephrine , endocrinology , cardiac function curve , receptor , dopamine
Aims Apelin, a novel peptide with a putative role in cardiovascular homeostasis, has gained interest as an endogenous inotrope, but has yet to be described following acute myocardial infarction (AMI) in man. We aimed to characterize plasma apelin concentrations following AMI and to examine its relationship with clinical and prognostic biomarkers. Methods and results Plasma concentrations of apelin, N‐terminal probrain natriuretic peptide (NT‐proBNP), norepinephrine, and arginine vasopressin were measured in 100 patients [mean age 58.9 ± 12 (SD) years, 77% male] admitted with AMI, with echocardiographic left ventricular (LV) ejection fraction <40%, at mean 46 h after admission and at 24 weeks. Cardiac magnetic resonance imaging was performed pre‐discharge and at 24 weeks. Thirty‐eight subjects with no cardiac history acted as controls. Apelin concentration was reduced early after AMI (0.54 ± 0.25 vs. 3.22 ± 3.01 ng/mL, P <0.001) and remained low at 24 weeks, although it did increase significantly from baseline to 0.62 ± 0.36 ng/mL, P = 0.030. Apelin had no relationship with any parameter of LV function over time. A relationship was found between baseline apelin and norepinephrine ( r = 0.26, P = 0.008). Both NT‐proBNP and norepinephrine correlated with adverse ventricular function after AMI. Conclusion Plasma apelin concentration is reduced early after AMI, increases significantly over time, but remains depressed at 24 weeks.