Demographic analysis and clinical outcomes of COVID-19 and myocardial infarction from a tertiary care centre in south India

Funding Acknowledgements Type of funding sources: None. Back ground – COVID-19  is reported in India from March 2020. It is known to cause  myocarditis , arrythmias and heart failure. COVID-19 infection has been proposed to be associated with myocardial infarction. PURPOSE –We intent to study outcomes of acute coronary syndrome associated with  COVID-19 patients . METHODS – This is a  single center case-control study done in an University hospital in south India ,  from May 2020 to October 2020 . Data of patients who came with acute coronary syndrome (ACS) with COVID- 19 were collected retrospectively from the hospital database. The clinical outcomes of the these patients were compared with the patients who were admitted in the hospital for ACS without  COVID -19  in the same period. RESULITS – 508  patients were admitted between May 2020 to October 2020  with ACS and out of which  58 patients were positive for COVID-19 and 450 patients were COVID-19 negative.  In COVID positive group, most of the patients were above 50 years  with 17 % of them being female sex.  60 %  were having diabetes and 44.8 % had hypertension . 55%  of them had STEMI with the rest being  NSTE- ACS . 43.1 %  patients were thrombolysed . 25% patients underwent revascularization either with  PCI / CABG . 10.3% died in the COVID - 19 positive group ,  at the same time there were only  2.2 % deaths in the control group . Most the patients were asymptomatic COVID-19 at presentation . Among the symptomatic COVID-19  patients the onset of myocardial infarction after COVID-19 ranged from 9 – 90 days . CONCLUSION – Acute coronary syndrome in COVID-19 patients  can present as late  as 3 months after index infection,  and these patients had higher mortality compared with those who did not have COVID -19 .