Open AccessThe role of G protein-coupled receptor kinase 4 in cardiomyocyte injury after myocardial infarction
Author(s) -
Liangpeng Li,
Wei Fu,
Xue Gong,
Zhi Chen,
Lina Tang,
Dezhong Yang,
Qinyu Liao,
Xuewei Xia,
Hao Wu,
Chao Liu,
Miao Tian,
Andi Zeng,
Lin Zhou,
Pedro A. José,
Ken Chen,
Wei Eric Wang,
Chunyu Zeng
Publication year - 2020
Publication title -
european heart journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.336
H-Index - 293
eISSN - 1522-9645
pISSN - 0195-668X
DOI - 10.1093/eurheartj/ehaa878
Subject(s) - autophagy , medicine , myocardial infarction , knockout mouse , genetically modified mouse , cardiac function curve , phosphorylation , apoptosis , endocrinology , transgene , receptor , heart failure , microbiology and biotechnology , biology , gene , biochemistry
G protein-coupled receptor kinase 4 (GRK4) has been reported to play an important role in hypertension, but little is known about its role in cardiomyocytes and myocardial infarction (MI). The goal of present study is to explore the role of GRK4 in the pathogenesis and progression of MI.