Open AccessGenetic aetiology of blood pressure relates to aortic stiffness with bi-directional causality: evidence from heritability, blood pressure polymorphisms, and Mendelian randomization
Author(s) -
Marina Cecelja,
Louise Keehn,
Ye Li,
Tim D. Spector,
Alun D. Hughes,
Phil Chowienczyk
Publication year - 2020
Publication title -
european heart journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.336
H-Index - 293
eISSN - 1522-9645
pISSN - 0195-668X
DOI - 10.1093/eurheartj/ehaa238
Subject(s) - mendelian randomization , arterial stiffness , pulse wave velocity , heritability , medicine , blood pressure , single nucleotide polymorphism , pulse pressure , genome wide association study , genetic association , cardiology , genetics , biology , gene , genotype , genetic variants
Haemodynamic determinants of blood pressure (BP) include cardiac output (CO), systemic vascular resistance (SVR), and arterial stiffness. We investigated the heritability of these phenotypes, their association with BP-related single-nucleotide polymorphisms (SNPs), and the causal association between BP and arterial stiffness.