Predicting global variation in infectious disease severity | Zendy

P. Jensen | Zendy; Henrik H. De Fine Licht | Zendy

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Predicting global variation in infectious disease severity

Author(s) -

P. Jensen,

Henrik H. De Fine Licht

Publication year - 2016

Publication title -

evolution medicine and public health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 22

ISSN - 2050-6201

DOI - 10.1093/emph/eow005

Subject(s) - demography , population , malaria , tuberculosis , medicine , infectious disease (medical specialty) , disease , mortality rate , case fatality rate , environmental health , immunology , pathology , sociology

Understanding the underlying causes for the variation in case-fatality-ratios (CFR) is important for assessing the mechanism governing global disparity in the burden of infectious diseases. Variation in CFR is likely to be driven by factors such as population genetics, demography, transmission patterns and general health status. We present data here that support the hypothsis that changes in CFRs for specific diseases may be the result of serial passage through different hosts. For example passage through adults may lead to lower CFR, whereas passage through children may have the opposite effect. Accordingly changes in CFR may occur in parallel with demographic transitions.

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