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Synaptotagmin 7 splice variants differentially regulate synaptic vesicle recycling
Author(s) -
Virmani Tuhin,
Han Weiping,
Liu Xinran,
Südhof Thomas C.,
Kavalali Ege T.
Publication year - 2003
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1093/emboj/cdg514
Subject(s) - library science , center (category theory) , gerontology , medicine , computer science , chemistry , crystallography
The speed of synaptic vesicle recycling determines the efficacy of neurotransmission during repetitive stimulation. Synaptotagmins are synaptic C 2 ‐domain proteins that are involved in exocytosis, but have also been linked to endocytosis. We now demonstrate that upon expression in transfected neurons, a short splice variant of synaptotagmin 7 that lacks C 2 ‐domains accelerates endocytic recycling of synaptic vesicles, whereas a longer splice variant that contains C 2 ‐domains decelerates recycling. These results suggest that alternative splicing of synaptotagmin 7 acts as a molecular switch, which targets vesicles to fast and slow recycling pathways.