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Premium Structure, function and evolution of the signal recognition particle
Author(s)
Nagai Kiyoshi,
Oubridge Chris,
Kuglstatter Andreas,
Menichelli Elena,
Isel Catherine,
Jovine Luca
Publication year2003
Publication title
the embo journal
Resource typeJournals
PublisherJohn Wiley & Sons
The signal recognition particle (SRP) is a ribonucleoprotein particle essential for the targeting of signal peptide‐bearing proteins to the prokaryotic plasma membrane or the eukaryotic endoplasmic reticulum membrane for secretion or membrane insertion. SRP binds to the signal peptide emerging from the exit site of the ribosome and forms a ribosome nascent chain (RNC)–SRP complex. The RNC–SRP complex then docks in a GTP‐dependent manner with a membrane‐anchored SRP receptor and the protein is translocated across or integrated into the membrane through a channel called the translocon. Recently considerable progress has been made in understanding the architecture and function of SRP.
Subject(s)biochemistry , biology , endoplasmic reticulum , gene , membrane , membrane protein , microbiology and biotechnology , peptide sequence , protein targeting , ribonucleoprotein , ribosome , rna , signal peptidase , signal peptide , signal recognition particle , signal recognition particle receptor , signal recognition particle rna , translocon
Language(s)English
SCImago Journal Rank7.484
H-Index392
eISSN1460-2075
pISSN0261-4189
DOI10.1093/emboj/cdg337

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