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Changing neighbours, changing behaviour: cell adhesion molecule‐mediated signalling during tumour progression
Author(s) -
Christofori Gerhard
Publication year - 2003
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1093/emboj/cdg228
Subject(s) - cell adhesion , cell adhesion molecule , intracellular , adhesion , cell , signalling , microbiology and biotechnology , cancer research , cell signaling , cancer cell , malignancy , chemistry , biology , cancer , signal transduction , medicine , pathology , biochemistry , genetics , organic chemistry
Changes in cell–cell and cell–matrix adhesion accompany the transition from benign tumours to invasive, malignant cancer and the subsequent metastatic dissemination of tumour cells. This review discusses a possible role of cell adhesion molecules not only in redirecting a tumour cell's adhesive capabilities but also in modulating intracellular signalling, and with it, tumour malignancy.