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FGFR1 is independently required in both developing mid‐ and hindbrain for sustained response to isthmic signals
Author(s) -
Trokovic Ras,
Trokovic Nina,
Hernesniemi Sanna,
Pirvola Ulla,
Vogt Weisenhorn Daniela M.,
Rossant Janet,
McMahon Andrew P.,
Wurst Wolfgang,
Partanen Juha
Publication year - 2003
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1093/emboj/cdg169
Subject(s) - library science , sociology , computer science
Fibroblast growth factors (FGFs) are signaling molecules of the isthmic organizer, which regulates development of the midbrain and cerebellum. Tissue‐specific inactivation of one of the FGF receptor (FGFR) genes, Fgfr1 , in the midbrain and rhombomere 1 of the hindbrain of mouse embryos results in deletion of the inferior colliculi in the posterior midbrain and vermis of the cerebellum. Analyses of both midbrain–hindbrain and midbrain‐specific Fgfr1 mutants suggest that after establishment of the isthmic organizer, FGFR1 is needed for continued response to the isthmic signals, and that it has direct functions on both sides of the organizer. In addition, FGFR1 appears to modify cell adhesion properties critical for maintaining a coherent organizing center. This may be achieved by regulating expression of specific cell‐adhesion molecules at the midbrain–hindbrain border.