Premium
The cell morphogenesis gene ANGUSTIFOLIA encodes a CtBP/BARS‐like protein and is involved in the control of the microtubule cytoskeleton
Author(s) -
Folkers U.,
Kirik V.,
Schöbinger U.,
Falk S.,
Krishnakumar S.,
Pollock M.A.,
Oppenheimer D.G.,
Day I.,
Reddy A.R.,
Jürgens G.,
Hülskamp M.
Publication year - 2002
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1093/emboj/21.6.1280
Subject(s) - biology , library science , computer science
The ANGUSTIFOLIA ( AN ) gene is required for leaf hair (trichome) branching and is also involved in polarized expansion underlying organ shape. Here we show that the AN gene encodes a C‐terminal binding proteins/brefeldin A ADP‐ribosylated substrates (CtBP/BARS) related protein. AN is expressed at low levels in all organs and the AN protein is localized in the cytoplasm. In an mutant trichomes, the organization of the actin cytoskeleton is normal but the distribution of microtubules is aberrant. A role of AN in the control of the microtubule cytoskeleton is further supported by the finding that AN genetically and physically interacts with ZWICHEL , a kinesin motor molecule involved in trichome branching. Our data suggest that CtBP/BARS‐like protein function in plants is directly associated with the microtubule cytoskeleton.