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The connection between transcription and genomic instability
Author(s) -
Aguilera Andrés
Publication year - 2002
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1093/emboj/21.3.195
Subject(s) - genome instability , transcription (linguistics) , biology , genetics , computational biology , transcription factor , dna , gene , dna damage , linguistics , philosophy
Transcription is a central aspect of DNA metabolism that takes place on the same substrate as replication, repair and recombination Not surprisingly, therefore, there is a physical and functional connection between these processes In recent years, transcription has proven to be a relevant player in the maintenance of genome integrity and in the induction of genetic instability and diversity The aim of this review is to provide an integrative view on how transcription can control different aspects of genomic integrity, by exploring different mechanisms that might be responsible for transcription‐associated mutation (TAM) and transcription‐associated recombination (TAR).