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The tripartite motif family identifies cell compartments
Author(s) -
Reymond Alexandre,
Meroni Germana,
Fantozzi Anna,
Merla Giuseppe,
Cairo Stefano,
Luzi Lucilla,
Riganelli Daniela,
Zanaria Elena,
Messali Silvia,
Cainarca Silvia,
Guffanti Alessandro,
Minucci Saverio,
Pelicci Pier Giuseppe,
Ballabio Andrea
Publication year - 2001
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1093/emboj/20.9.2140
Subject(s) - biology , trim , motif (music) , computational biology , gene , genetics , sequence motif , microbiology and biotechnology , computer science , operating system , physics , acoustics
A functional genomic approach, based on systematic data gathering, was used to characterize a family of proteins containing a tri partite m otif (TRIM). A total of 37 TRIM genes/proteins were studied, 21 of which were novel. The results demonstrate that TRIM proteins share a common function: by means of homo‐multimerization they identify specific cell compartments.