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Establishment and maintenance of sister chromatid cohesion in fission yeast by a unique mechanism
Author(s) -
Tanaka Koichi,
Hao Zhonglin,
Kai Mihoko,
Okayama Hiroto
Publication year - 2001
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1093/emboj/20.20.5779
Subject(s) - establishment of sister chromatid cohesion , chromatid , homologous chromosome , cohesion (chemistry) , sister chromatids , cohesin , genetics , homologous recombination , biology , dna replication , pairing , dna , microbiology and biotechnology , chemistry , physics , chromosome , superconductivity , quantum mechanics , gene , organic chemistry , chromatin
During S phase, chromatid cohesion is established only between nascent sisters and with faithful pairing along their entire region, but how this is ensured is unknown. Here we report that sister chromatid cohesion is formed and maintained by a unique mechanism. In fission yeast, Eso1p, functioning in close coupling to DNA replication, establishes sister chromatid cohesion whereas the newly identified Cohesin‐associated protein Pds5p hinders the establishment of cohesion until counteracted by Eso1p, yet stabilizes cohesion once it is established. Eso1p interacts physically with Pds5p via its Ctf7p/Eco1p‐homologous domain.