Premium
Impaired learning with enhanced hippocampal long‐term potentiation in PTPδ‐deficient mice
Author(s) -
Uetani Noriko,
Kato Kunio,
Ogura Hiro,
Mizuno Kazuya,
Kawano Kano,
Mikoshiba Katsuhiko,
Yakura Hidetaka,
Asano Masahide,
Iwakura Yoichiro
Publication year - 2000
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1093/emboj/19.12.2775
Subject(s) - long term potentiation , hippocampal formation , hippocampus , biology , neuroscience , morris water navigation task , synaptic plasticity , neuroplasticity , water maze , receptor , biochemistry
Protein tyrosine phosphatase δ (PTPδ) is a receptor‐type PTP expressed in the specialized regions of the brain including the hippocampal CA2 and CA3, B lymphocytes and thymic medulla. To elucidate the physiological roles of PTPδ, PTPδ‐deficient mice were produced by gene targeting. It was found that PTPδ‐deficient mice were semi‐lethal due to insufficient food intake. They also exhibited learning impairment in the Morris water maze, reinforced T‐maze and radial arm maze tasks. Interestingly, although the histology of the hippocampus appeared normal, the magnitudes of long‐term potentiation (LTP) induced at hippocampal CA1 and CA3 synapses were significantly enhanced in PTPδ‐deficient mice, with augmented paired‐pulse facilitation in the CA1 region. Thus, it was shown that PTPδ plays important roles in regulating hippocampal LTP and learning processes, and that hippocampal LTP does not necessarily positively correlate with spatial learning ability. To our knowledge, this is the first report of a specific PTP involved in the regulation of synaptic plasticity or in the processes regulating learning and memory.