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TREK‐1 is a heat‐activated background K + channel
Author(s) -
Maingret François,
Lauritzen Inger,
Patel Amanda J.,
Heurteaux Catherine,
Reyes Roberto,
Lesage Florian,
Lazdunski Michel,
Honoré Eric
Publication year - 2000
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1093/emboj/19.11.2483
Subject(s) - thermoreceptor , dorsal root ganglion , trpm8 , sensory system , chemistry , neuroscience , receptor , biophysics , biology , microbiology and biotechnology , endocrinology , anatomy , transient receptor potential channel , biochemistry , trpv1
Peripheral and central thermoreceptors are involved in sensing ambient and body temperature, respectively. Specialized cold and warm receptors are present in dorsal root ganglion sensory fibres as well as in the anterior/preoptic hypothalamus. The two‐pore domain mechano‐gated K + channel TREK‐1 is highly expressed within these areas. Moreover, TREK‐1 is opened gradually and reversibly by heat. A 10°C rise enhances TREK‐1 current amplitude by ∼7‐fold. Prostaglandin E2 and cAMP, which are strong sensitizers of peripheral and central thermoreceptors, reverse the thermal opening of TREK‐1 via protein kinase A‐mediated phosphorylation of Ser333. Expression of TREK‐1 in peripheral sensory neurons as well as in central hypothalamic neurons makes this K + channel an ideal candidate as a physiological thermoreceptor.