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The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis
Author(s) -
Guo Wei,
Roth Dagmar,
WalchSolimena Christiane,
Novick Peter
Publication year - 1999
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1093/emboj/18.4.1071
Subject(s) - exocyst , exocytosis , biology , effector , secretory vesicle , vesicle , microbiology and biotechnology , secretory pathway , secretion , extracellular vesicles , golgi apparatus , membrane , biochemistry , endoplasmic reticulum
Polarized secretion requires proper targeting of secretory vesicles to specific sites on the plasma membrane. Here we report that the exocyst complex plays a key role in vesicle targeting. Sec15p, an exocyst component, can associate with secretory vesicles and interact specifically with the rab GTPase, Sec4p, in its GTP‐bound form. A chain of protein–protein interactions leads from Sec4p and Sec15p on the vesicle, through various subunits of the exocyst, to Sec3p, which marks the sites of exocytosis on the plasma membrane. Sec4p may control the assembly of the exocyst. The exocyst may therefore function as a rab effector system for targeted secretion.