Premium
Dbp5p, a cytosolic RNA helicase, is required for poly(A) + RNA export
Author(s) -
Tseng Stephanie S. I,
Weaver Paul L.,
Liu Yan,
Hitomi Midori,
Tartakoff Alan M.,
Chang TienHsien
Publication year - 1998
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1093/emboj/17.9.2651
Subject(s) - biology , rna , rna helicase a , helicase , cytosol , microbiology and biotechnology , genetics , biochemistry , gene , enzyme
The DBP5 gene encodes a putative RNA helicase of unknown function in the yeast Saccharomyces cerevisiae . It is shown here that Dbp5p is an ATP‐dependent RNA helicase required for polyadenylated [poly(A) + ] RNA export. Surprisingly, Dbp5p is present predominantly, if not exclusively, in the cytoplasm, and is highly enriched around the nuclear envelope. This observation raises the possibility that Dbp5p may play a role in unloading or remodeling messenger RNA particles (mRNPs) upon arrival in the cytoplasm and in coupling mRNP export and translation. The functions of Dbp5p are likely to be conserved, since its potential homologues can be found in a variety of eukaryotic cells.