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Nuclear history of a pre‐mRNA determines the translational activity of cytoplasmic mRNA
Author(s) -
Matsumoto Ken,
Wassarman Karen Montzka,
Wolffe Alan P.
Publication year - 1998
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1093/emboj/17.7.2107
Subject(s) - biology , messenger rna , intron , gene silencing , microbiology and biotechnology , cytoplasm , transcription (linguistics) , precursor mrna , gene expression , translation (biology) , rna , gene , genetics , rna splicing , linguistics , philosophy
The pathways of synthesis and maturation of pre‐messenger RNA in the nucleus have a direct effect on the translational efficiency of mRNA in the cytoplasm. The transcription of intron‐less mRNA in vivo directs this mRNA towards translational silencing. The presence of an intron at the 5′ end of the transcript relieves this silencing, whereas an intron at the 3′ end further represses translation. These regulatory events are strongly dependent on the transcription of pre‐mRNA in the nucleus. The impact of nuclear history on regulatory events in the cytoplasm provides a novel mechanism for the control of gene expression.