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Targeted disruption of the ubiquitous CNC‐bZIP transcription factor, Nrf‐1, results in anemia and embryonic lethality in mice
Author(s) -
Chan Jefferson Y.,
Kwong Mandy,
Lu Ronghua,
Chang Judy,
Wang Brooke,
Yen T.S.Benedict,
Kan Yuet Wai
Publication year - 1998
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1093/emboj/17.6.1779
Subject(s) - biology , lethality , transcription factor , embryonic stem cell , microbiology and biotechnology , genetics , phenotype , gene
The CNC‐basic leucine zipper (CNC‐bZIP) family is a subfamily of bZIP proteins identified from independent searches for factors that bind the AP‐1‐like cis ‐elements in the β‐globin locus control region. Three members, p45‐Nf‐e2, Nrf‐1 and Nrf‐2 have been identified in mammals. Expression of p45‐Nf‐e2 is largely restricted to hematopoietic cells while Nrf‐1 and Nrf‐2 are expressed in a wide range of tissues. To determine the function of Nrf‐1, targeted disruption of the Nrf‐1 gene was carried out. Homozygous Nrf‐1 mutant mice are anemic due to a non‐cell autonomous defect in definitive erythropoiesis and die in utero .