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Fission yeast Csk1 is a CAK‐activating kinase (CAKAK)
Author(s) -
Hermand Damien,
Pihlak Arno,
Westerling Thomas,
Damagnez Véronique,
Vandenhaute Jean,
Cottarel Guillaume,
Mäkelä Tomi P.
Publication year - 1998
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1093/emboj/17.24.7230
Subject(s) - biology , cyclin dependent kinase 7 , cyclin dependent kinase , schizosaccharomyces pombe , microbiology and biotechnology , schizosaccharomyces , kinase , cyclin dependent kinase 1 , cyclin dependent kinase 2 , cyclin dependent kinase 4 , biochemistry , yeast , saccharomyces cerevisiae , protein kinase a , cell cycle , cell
Cell cycle progression is dependent on the sequential activity of cyclin‐dependent kinases (CDKs). For full activity, CDKs require an activating phosphorylation of a conserved residue (corresponding to Thr160 in human CDK2) carried out by the CDK‐activating kinase (CAK). Two distinct CAK kinases have been described: in budding yeast Saccharomyces cerevisiae , the Cak1/Civ1 kinase is responsible for CAK activity. In several other species including human, Xenopus, Drosophila and fission yeast Schizosaccharomyces pombe , CAK has been identified as a complex homologous to CDK7–cyclin H (Mcs6–Mcs2 in fission yeast). Here we identify the fission yeast Csk1 kinase as an in vivo activating kinase of the Mcs6–Mcs2 CAK defining Csk1 as a CAK‐activating kinase (CAKAK).