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The winding road from adhesive receptors to the nucleus
Author(s) -
Defilippi Paola,
Vallés Ana M
Publication year - 2002
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1093/embo-reports/kvf076
Subject(s) - receptor , nucleus , microbiology and biotechnology , adhesive , biology , chemistry , business , biochemistry , organic chemistry , layer (electronics)
EURESCO conferences on adhesive interactions were established in 1993 in the Life Sciences programs of the European Science Foundation. Every 2 years, scientists involved in the different fields of adhesive interactions come for a 3‐day meeting and exchange their latest results in a conference format of about 40 invited speakers and a poster session. This format promotes discussion and a fruitful exchange of results and ideas and is considered by ‘old’ and ‘new’ investigators in the field to be one of the most attractive European meetings on cell adhesion.![][1] Adhesive receptors are responsible for general tissue architecture and cell behaviour. They modulate mechanical adhesive interactions and regulate a cascade of intracellular signalling pathways (for reviews, see Giancotti and Ruoslahti, 1999; Gumbiner, 2000). In most cases, the end‐point of the receptor‐induced signalling cascade is the regulation of gene expression and corresponding modifications in cell metabolism, differentiation or proliferation. Adhesion receptor signalling, regulation of gene expression and their relevance to cell growth, differentiation, survival and development were the topics of the 2001 European Science Foundation Conference, organized by G. Tarone (Turin, Italy) and J.‐L. Duband (Paris, France).Adhesive receptors, which include integrins, cadherins, selectins and the immunoglobulin superfamily, have no catalytic function, and their interactions with other transducing molecules are crucial for signalling. Many examples of interactions of adhesive receptors with cellular effectors were presented, and the data generated from in vitro cell cultures were often corroborated in in vivo systems, designed to determine the contribution of each pathway to a given function. In this report, we highlight some of the salient themes that emerged.### Pathways leading to gene expression: lessons from global expression analysesIn the late 1980s, the pioneering work of S. Haskill (Eierman et al ., 1989) indicated that cell adhesion to the extracellular matrix (ECM) controls the expression of specific genes. It is now known that integrins are … [1]: /embed/graphic-1.gif