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The renaissance of aminoacyl‐tRNA synthesis
Author(s) -
Ibba Michael,
Söll Dieter
Publication year - 2001
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1093/embo-reports/kve095
Subject(s) - aminoacyl trna synthetase , aminoacyl trna , protein biosynthesis , transfer rna , the renaissance , computational biology , genetic code , synthetic biology , amino acyl trna synthetases , biology , amino acid , genetics , gene , rna , art , art history
The role of tRNA as the adaptor in protein synthesis has held an enduring fascination for molecular biologists. Over four decades of study, taking in numerous milestones in molecular biology, led to what was widely held to be a fairly complete picture of how tRNAs and amino acids are paired prior to protein synthesis. However, recent developments in genomics and structural biology have revealed an unexpected array of new enzymes, pathways and mechanisms involved in aminoacyl‐tRNA synthesis. As a more complete picture of aminoacyl‐tRNA synthesis now begins to emerge, the high degree of evolutionary diversity in this universal and essential process is becoming clearer.