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Structural basis for selectivity and toxicity of ribosomal antibiotics
Author(s) -
Böttger Erik C,
Springer Burkhard,
Prammananan Therdsak,
Kidan Yishak,
Sander Peter
Publication year - 2001
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1093/embo-reports/kve062
Subject(s) - antibiotics , toxicity , ribosomal rna , biology , chemistry , microbiology and biotechnology , computational biology , biochemistry , gene , organic chemistry
Ribosomal antibiotics must discriminate between bacterial and eukaryotic ribosomes to various extents. Despite major differences in bacterial and eukaryotic ribosome structure, a single nucleotide or amino acid determines the selectivity of drugs affecting protein synthesis. Analysis of resistance mutations in bacteria allows the prediction of whether cytoplasmic or mitochondrial ribosomes in eukaryotic cells will be sensitive to the drug. This has important implications for drug specificity and toxicity. Together with recent data on the structure of ribosomal subunits these data provide the basis for development of new ribosomal antibiotics by rationale drug design.