FDG-PET reveals improved cardiac regeneration and attenuated adverse remodelling following Sitagliptin + G-CSF therapy after acute myocardial infarction | Zendy

Lisa Groß | Zendy; Lisa Paintmayer | Zendy; Sebastian Lehner | Zendy; Lydia Brandl | Zendy; Christoph Brenner | Zendy; Ulrich Grabmaier | Zendy; Bruno Hüber | Zendy; Peter Bartenstein | Zendy; Hans-Diogenes Theiss | Zendy; WolfgangMichael Franz | Zendy; Steffen Maßberg | Zendy; Andrei Todica | Zendy; Stefan Brunner | Zendy

Open Access

FDG-PET reveals improved cardiac regeneration and attenuated adverse remodelling following Sitagliptin + G-CSF therapy after acute myocardial infarction

Author(s) -

Lisa Groß,

Lisa Paintmayer,

Sebastian Lehner,

Lydia Brandl,

Christoph Brenner,

Ulrich Grabmaier,

Bruno Hüber,

Peter Bartenstein,

Hans-Diogenes Theiss,

WolfgangMichael Franz,

Steffen Maßberg,

Andrei Todica,

Stefan Brunner

Publication year - 2015

Publication title -

european heart journal - cardiovascular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.576

H-Index - 92

eISSN - 2047-2412

pISSN - 2047-2404

DOI - 10.1093/ehjci/jev237

Subject(s) - myocardial infarction , medicine , sitagliptin , bone marrow , ligation , cardiology , placebo , ventricular remodeling , ejection fraction , heart failure , pathology , insulin , alternative medicine , metformin

Dual therapy comprising G-CSF for mobilization of bone marrow-derived progenitor cells (BMPCs), with simultaneous pharmacological inhibition of dipeptidylpeptidase-IV for enhanced myocardial recruitment of circulating BMPC via the SDF-1α/CXCR4-axis, has been shown to improve survival after acute myocardial infarction (AMI). Using an innovative method to provide non-invasive serial in vivo measurements and information on metabolic processes, we aimed to substantiate the possible effects of this therapeutic concept on cardiac remodelling after AMI using 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography (FDG-PET).

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